Selected Publications
Miano C, Morselli A, Pontis F, Bongiovanni C, Sacchi F, Da Pra S, Romaniello D, Tassinari R, Sgarzi M, Pantano E, Ventura C, Lauriola M and D’Uva G.
Loss of cell anchorage triggers NRG1/HER2 axis in basal-like/triple-negative breast cells.
Cancers, 2022
Bongiovanni C, Sacchi F, Da Pra S, Pantano E, Miano C, Morelli MB, D’Uva G.
Reawakening the Intrinsic Cardiac Regenerative Potential: Molecular Strategies to Boost Dedifferentiation and Proliferation of Endogenous Cardiomyocytes.
Frontiers in Cardiovascular Medicine, 2021
Del Monte-Nieto G, Ramialison M, Adam AAS, Wu B, Aharonov A, D’Uva G, Bourke LM, Pitulescu ME, Chen H, de la Pompa JL, Shou W, Adams RH, Harten SK, Tzahor E, Zhou B and Harvey RP
Control of cardiac jelly dynamics by NOTCH1 and NRG1 defines the building plan for trabeculation.
Nature, 2018
Sampaio-Pinto V, Rodrigues S, Laúndos T, Silva E, Nóvoa F, Silva A, Cerqueira R, Resende T, Pianca N, Leite-Moreira A, D’Uva G, Thorsteinsdóttir S, Pinto-do-Ó P, Santos Nascimento D
Neonatal Apex Resection Triggers Cardiomyocyte Proliferation, Neovascularization and Functional Recovery in Spite of Local Fibrosis.
Stem Cell Reports, 2018
D’Uva G, Baci D, Albini A, Noonan DM
Cancer chemoprevention revisited: Cytochrome P450 family 1B1 as a target in the tumor and the microenvironment.
Cancer Treatment Reviews, 2017
Gelfo V, Rodia MT, Pucci M, Dall’Ora M, Santi S, Solmi R, Roth L, Lindzen M, Bonafè M, Bertotti A, Caramelli E, Lollini PL, Trusolino L, Yarden Y, D’Uva G*, Lauriola M.
A module of inflammatory cytokines defines resistance of colorectal cancer to EGFR inhibitors.
Oncotarget, 2016
(* co-last author)
D’Uva G and Lauriola M.
Towards the emerging crosstalk: ERBB family and steroid hormones.
Seminars in Cell and Developmental Biology, 2016
(* co-correponding author)
D’Uva G and Tzahor E.
The key roles of ERBB2 in cardiac regeneration.
Cell Cycle, 2015
D’Uva G, Aharonov A, Lauriola M, Kain D, Yahalom-Ronen Y, Carvalho S, Weisinger K, Bassat E, Rajchman D, Yifa O, Lysenko M, Konfino T, Hegesh J, Brenner O, Neeman M, Yarden Y, Leor J, Sarig R, Harvey RP and Tzahor E.
ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation.
Nature Cell Biology, 2015
Awards and honours:
• commented in Nature: Regenerative biology: Neuregulin 1 makes heart muscle
• commented in Science: New hope for heart attack sufferers?
• highlighted in Nature Reviews Drug Discovery: Research Highlights
• highlighted by National Association for Biomedical Research (NABR: The Essential Need for Animals in Medical Research as an important example of biomedical research that justifies the essential need for animals in medical research.
International media coverage, including The Guardian, The Sydney Morning Herald, SKY NEWS, The Times of Israel, Il Sole 24 Ore and La Repubblica
Lauriola M, Enuka Y, Zeisel A, D’Uva G, Roth L, Sharon-Sevilla M, Lindzen M, Sharma K, Nevo N, Feldman M, Carvalho S, Cohen-Dvashi H, Kedmi M, Ben-Chetrit N, Chen A, Solmi R, Wiemann S, Schmitt F, Domany E and Yarden Y.
Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment.
Nature Communications, 2014
International media coverage, including Time, Daily Mail, Forbes and Huffington Post
D’Uva G*, Bertoni S, Lauriola M, De Carolis S, Pacilli A, D’Anello L, Santini D, Taffurelli M, Ceccarelli C, Yarden Y, Montanaro L, Bonafé M and Storci G.
Beta-catenin/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxia.
PLoS One, 2013
(* co-corresponding author)
Kollet O*, Vagima Y*, D’Uva G, Golan K, Canaani J, Itkin T, Gur-Cohen S, Kalinkovich A, Caglio G, Medaglia C, Ludin A, Lapid K, Shezen E, Neufeld-Cohen A, Varol D, Chen A and Lapidot T.
Physiologic corticosterone oscillations regulate murine hematopoietic stem/progenitor cell proliferation and CXCL12 expression by bone marrow stromal progenitors.
Leukemia, 2013
(*equal contribution)
Lapid K, Itkin T, D’Uva G, Ovadya Y, Ludin A, Caglio G, Kalinkovich A, Golan K, Porat Z, Zollo M and Lapidot T.
GSK3β regulates physiological migration of stem/progenitor cells via cytoskeletal rearrangement.
Journal of Clinical Investigation, 2013
Ludin A, Itkin T, Gur-Cohen S, Mildner A, Shezen E, Golan K, Kollet O, Kalinkovich A, Porat Z, D’Uva G, Schajnovitz A, Voronov E, Brenner DA, Apte RN, Jung S and Lapidot T.
Monocytes-macrophages that express α-smooth muscle actin preserve primitive hematopoietic cells in the bone marrow.
Nature Immunology, 2012
Schajnovitz A, Itkin T, D’Uva G, Kalinkovich A, Golan K, Ludin A, Cohen D, Shulman Z, Avigdor A, Nagler A, Kollet O, Seger R, Lapidot T.
CXCL12 secretion by bone marrow stromal cells is dependent on cell contact and mediated by connexin-43 and connexin-45 gap junctions.
Nature Immunology, 2011
Awards and honours:
• selected for the cover of Nature Immunology (May 2011)
• commented in Nature Immunology – News and Views
Full publication list available here
Patents
TZAHOR E, D’UVA GM, SARIG R, AHARONOV A, HARVEY RP and UMANSKY KB.
“METHODS, KITS AND DEVICES FOR PROMOTING CARDIAC REGENERATION”
Issued in USA: Patent #2016-0326250-A1